华北岩黄芪化学成分研究

摘要

Aim To study the chemical constituents of Hedysarum gmelinii. Methods The constituents were separated and purified by different methods of chromatography, and their structures were elucidated by IR, MS and NMR. Results Eight compounds were isolated from Hedysarum gmelinii, including three triterpenoids, two flavonoids and two other compounds. Their structures were identified as squasapogenol (1), soyasapogenol (2), lupeol (3), 3, 9-dihydroxy coumestan (4), 3-hydroxy-9-methoxy pterocarpan (5), β-sitosterol (6), palmatic acid (7), and hexadecanoic acid 2, 3-dihydroxypropyl ester (8). Conclusion All the compounds have been isolated from this plant for the first time. Compounds 1-4 and 8 were obtained from this genus for the first time. The NMR data of 1 are reported for the first time.%目的对华北岩黄芪Hedysarum gmelinii的化学成分进行研究. 方法用色谱法分离, 并用各种波谱法对化合物的结构进行鉴定.结果从华北岩黄芪的根部分离鉴定了8个化合物,其结构分别为:圆果皂苷元 (1)、黄豆醇B (2)、羽扇豆醇 (3)、香豆雌酚 (4)、3-羟基-9-甲氧基紫檀烷 (5)、β-谷甾醇 (6)、软脂酸 (7)和α-软脂酸甘油酯 (8).结论以上化合物均为首次从该植物中获得,其中化合物1-4, 8为首次从本属植物中获得,本文对圆果皂苷元的1H、13C NMR谱首次进行了报道.