慢性病及其治疗药物可能会影响肺癌患者术后5年生存率

摘要

In this study,we aimed to investigate the influencing factors of postoperative 5-year survival rate in non small-cell lung cancer (NSCLC) patients with stage Ⅰ-Ⅲ.We enrolled 220 patients who underwent surgical operation and survived longer than 3 months,with histologically confirmed adenocarcinoma or squamous cell carcinoma from Jan.2009 to Dec.2009.Multiple variables,like age,gender,smoking,alcohol,obesity,family history of cancer,diabetes,hypertension,antidiabetic drugs,tumor staging,pathology,treatments,surgical side as well as lipid levels,were selected.We found that tumor staging was associated with 5-year survival rate of stage Ⅰ-Ⅲ NSCLC patients by univariate analysis.Furthermore,diabetes mellitus,hypertension and surgical side were associated with the overall survival of NSCLC patients with stage Ⅰ,stage Ⅱ and stage Ⅲ,respectively.In conclusion,the status of chronic disease had potential effect on the postoperative 5-year survival rate of lung cancer patients.%本研究旨在探讨非小细胞肺癌(NSCLC)Ⅰ～Ⅲ期患者术后5年生存率的影响因素.我们收集了2009年1月至2009年12月间经组织学证实的腺癌或鳞状细胞癌的NSCLC术后患者共220例,且存活期大于3个月.影响因素有多个变量,如年龄、性别、吸烟、酒精、肥胖、糖尿病、高血压、抗糖尿病药物、肿瘤分期、病理学、治疗方式、发病部位(左侧或右侧)以及脂质水平.通过单变量分析,我们发现肿瘤分期与Ⅰ～Ⅲ期NSCLC患者的5年生存率相关.此外,糖尿病、高血压和发病部位(左侧或右侧)分别与NSCLC患者Ⅰ期,Ⅱ期和Ⅲ期的5年生存率相关.由此可得,慢性病及其治疗药物可能对肺癌患者术后5年生存率具有潜在影响.