早产儿脂肪乳剂应用剂量的临床研究

摘要

Objective To explore the dosage and adverse reaction of fat emulsion in preterm infants.Methods The observation group were treated with fat emulsion injection starting dose of 1 g/(kg · d), the uniform increase of 1 g / kg daily; the control group received intralipid injection starting dose of 0.5 g /(kg · d). At the same time, according to the specific situation, the two groups of children were given formula enteral feeding, to be 100 kcal/ after enteral nutrition, to stop the parenteral nutrition support. The clinical situation, laboratory test indexes and weight gain of the two groups were compared and observed.Results The observation group in the recovery of birth weight and the average time of the PN, discharge weight, time of high bilirubin and serum bilirubin values were better than those of the control group(P<0.05); the two groups in the occurrence jaundice to the end time and duration of hospitalization was no significant difference(P> 0.05). The two groups were not to occur EUGR. After the end of the PN, the comparison of laboratory parameters, PLT, TC, TG, ALT, TB, TBA, GGT was no significant difference (P> 0.05).Conclusion Given proper fat emulsion, strengthen nutrition interventions in preterm children can improve the quality of the prognosis of preterm children.%目的：探究早产儿脂肪乳剂应用剂量及不良反应情况。方法将50例早产儿随机分为观察组及对照组，每组25例，在常规输液的基础上，观察组给予脂肪乳注射液起始剂量为1 g/（kg·d），每天匀速增加1 g/kg；对照组给予脂肪乳注射液起始剂量为0.5 g/（kg·d），每天匀速增加0.5 g/kg，两组给予脂肪乳注射液最高剂量为3 g/（kg·d），24 h经输液泵均匀输注，同时根据具体情况，两组患儿均给予配方奶肠内喂养，待肠内营养达到100 kcal/（kg·d）后，停止肠外营养支持，对比观察两组患儿临床情况、实验室检测指标以及体重增长情况。结果观察组在恢复出生体重时间、肠外营养支持（PN）平均时间、出院体重、高胆红素血症时间及血清胆红素最高值上明显优于对照组，差异均具有统计学意义（P＜0.05）；两组患儿在发生黄疸至结束时间和住院时间无明显差异（P＞0.05）。两组均未发生宫外生长迟缓。肠外营养支持（PN）结束后，实验室指标对比中， PLT、TC、TG、ALT、TB、TBA、GGT之间无明显差异（P＞0.05）。结论对早产儿早期给予大剂量脂肪乳剂，加强对早产儿的营养干预，更有利于早产儿体重增长，缩短住院时间及肠外营养使用时间，从而满足生长追赶的需要，达到提高早产儿预后质量的目的，并且不增加不良反应。