老年冠心病患者血清尿酸水平与冠脉病变程度的相关性分析

摘要

Objective:To evaluate the relationship between the serum uric acid (SUA)level and the severity of coronary lesions in elderly patients with coronary heart disease(CHD).Methods:A total of 255 elderly patients who received angiography and hospitalized in the department from January 2008 to December 2011 were collected. According to the results of coronary angiography, the patients were divided into CHD group (n=183)and non-CHD group(n=72),in turn,divided into single-,double- and triple-vessel disease groups according to the number of coronary artery branches with lesions,the serum uric acid level was determined,and the serum uric acid levels of different groups and the association between the serum uric acid level and coronary lesions were analyzed.Results:Level of serum uric acid in CHD group (321.825 ±113.483?mol/L) was significantly higher than that of non-CHD group(260.948±76.438?mol/L,P<0.01).The serum uric acid levels of the single-vessel group, double-vessel group and triple-vessel group were 314.03±112.313?mol/L,317.08±108.739?mol/L and 338.43±107.762?mol/L.There were no significant difference among them(all P>0.05).The further multivari-ate logistic regression analysis showed that serum uric acid was significantly associated with coronary lesions after other risk factors were adjusted (P=0.014,OR=1.005,95% CI-.1.001~1.008).Conclusion Serum uric acid levels are correlated with coronary atherosclerotic heart disease and the severity of coronary lesions,and it's an important biochemical indicator reflecting the severity of CHD.Early intervention of high level of serum uric acid may decline the occurrence of acute coronary heart disease.%目的:探讨老年冠状动脉造影患者血清尿酸水平与冠状动脉病变严重程度之间的关系.方法:入选2008年1月～2011年12月在我科住院并行冠脉造影检查的老年患者255例,根据冠状动脉造影结果分为冠心病组(n=183)和非冠心病组(n=72),根据冠脉病变血管支数分为单支病变组、双支病变组和3支病变组,测定患者空腹血清尿酸水平并进行比较,分析血尿酸与冠状动脉病变严重程度的关系.结果:冠心病组患者的血清尿酸水平(321.825±113.483μmol/L)显著高于非冠心病组(260.948±76.438μmol/L,P＜0.01).单支病变组、双支病变组、3支病变组血尿酸分别为314.03±112.313、317.08±108.739和338.43±1 07.762μmol/L,各组间无统计学差异(均P＞0.05).经logistic回归校正相关因素后,血尿酸水平与冠心病的发病风险显著相关(P=0.014,OR=1.005,95％CI:1.001～1.008).结论:血尿酸水平与冠状动脉病变的严重程度密切相关,是预测冠心病发病风险的独立危险因素之一.对其早期干预可能降低急性心血管事件的发生.