妊娠期高血压疾病患者乳酸脱氢酶水平的变化及其对妊娠结局的影响∗

摘要

目的：探讨妊娠期高血压疾病患者乳酸脱氢酶(LDH)水平的变化及其对妊娠结局的影响。方法选择妊娠期高血压疾病患者42例,根据高血压程度不同分为重症组(n=20)和轻症组(n=22),另选取同期住院正常孕产妇25例为对照组。观察各组血清乳酸、LDH、尿酸(UA)、尿微量白蛋白(mAlb)水平的变化及妊娠结局。结果重症组及轻症组血清乳酸及 LDH 含量均明显高于对照组,且随病情加重,血清乳酸及 LDH 水平呈上升趋势,差异有统计学意义(P <0.01)；与 LDH≤240 IU/L 者比较,LDH>240 IU/L 者的 UA 及 mAlb 水平明显升高；UA、mAlb 与 LDH 浓度呈正相关(r 值分别为0.416、0.398,P <0.05)；围产儿体质量、Apgar 评分明显降低(P <0.01)。结论妊娠期高血压疾病患者 LDH 水平随病情严重程度而升高,LDH 水平与妊娠结局密切相关,可作为判断孕产预后的辅助指标。%Objective To explore the change of lactate dehydrogenase (LDH)level in pregnant women with hypertensive disorders complicating pregnancy and its influence on pregnant outcomes.Methods A total of 42 pregnant women with hypertensive disorders complicating pregnancy were selected and divided into severe group (n= 20 ) and mild group (n = 22 ) according to the disease conditions.Another 25 normal pregnant women hospitalized at the same period served as control group.Serum lactic acid,LDH,serum uric acid (UA and microalbuminuria (mAlb)levels as well as pregnant outcomes were observed in all groups.Results Serum lactic acid and LDH levels were evidently higher in moderate and mild groups than in control group,and increased along with the exacerbation of disease condition,and all differences were statistically significant (P <0.01).UA and mAlb levels were markedly higher but body mass of peri-natal infants and Apgar score were significantly lower in patients with LDH≤240 IU/L than in those with LDH>240 IU/L (P <0.01).Conclusion LDH level increases along with the exacerbation of disease condition of pregnant women with hypertensive disorders complicating pregnancy,and it is also closely associated with pregnant outcomes.Therefore,LDH level can be used as a secondary indicator for the prognosis of pregnant women.