hMSH6和P53在散发性结肠癌中的表达及意义

摘要

目的：探讨hMSH6和P53蛋白在散发性结肠癌(SCC)中的表达及二者与SCC临床病理特征的关系。方法：采用免疫组化法检测60例SCC以及癌旁组织hMSH6和P53蛋白的表达情况。结果：SCC中hMSH6蛋白的阳性表达率明显低于癌旁组织，P53蛋白的阳性表达率明显高于癌旁组织(P＜0.01，P＜0.05)。SCC中hMSH6蛋白的表达与肿瘤浸润深度和发生部位有关(P＜0.05)；P53蛋白的表达与SCC临床病理特征均无关(P＞0.05)。SCC中，hMSH6与P53蛋白的表达呈负相关(r=-0.321，P＜0.05)。结论：hMSH6和P53蛋白的异常表达与SCC的发生发展和临床病理特征有关。%Objective:To investigate the expression of hMSH6 and P53 protein in sporadic colorectal carcinoma (SCC) and their relationships with clinicopathologic features of SCC. Methods:Immunohistochemical staining was used to detect the expression of hMSH6 and P53 protein in 60 cases SCC and para-carcinoma tissue.Results:In SCC, the hMSH6 protein expression was obviously lower than that in para-carcinoma tissue;while the P53 protein expression was obviously higher (P<0.01, P<0.05). In SCC, the positive expression of hMSH6 protein had relations with inifltration depth and location of tumor (P<0.05);but the P53 protein expression had no relations with any clinicopathologic features of SCC. In SCC, the hMSH6 protein expression negatively correlated with P53 protein expression (r=-0.321, P<0.05).Conclusions:Abnormal expression of hMSH6 and P53 protein involves in development and clinicopathologic features of SCC.