Objective: To investigate the functional magnetic resonance imaging (fMRI) data of deception in antisocial personality disorders (ASPD).Methods: A total of 32 criminals meeting the criteria for ASPD underwent fMRI at 1.5T while responding truthfully questions or lying. We compared the brain activities between truth-telling and lie-telling, and then computed the correlation coefficient between the contrast brain activities and the inclination to deception.Results: The left anterior cingulate gyrus, the bilateral dorsolateral prefrontal cortex, and left inferior parietal lobule were associated with the executive aspects of deception among people with ASPD. But with the greater inclination to deception, the blood oxygen level dependent (BOLD) activities in those regions decreased Conclusion: Evaluations of truthful and untruthful communications pertaining to ASPD subjects may be differentiated in terms of brain BOLD activities, though those activities may decrease in habitual liars, which remains a challenge to the diagnostic accuracy in lie detection.%目的:研究反社会人格的罪犯说谎时的功能磁共振情况.方法:对32个满足反社会人格标准的男性罪犯进行功能磁共振,分析他们在说真话和说假话时的脑区激活差异以及习惯性说谎程度与激活脑区强弱之间的关系.结果:反社会人格障碍患者左扣带回前部,双侧的背外侧前额叶,左顶下小叶与其欺骗行为的执行相关.并且随着善于说谎程度的加强,这些区域的激活强度呈下降趋势.结论:利用大脑的血氧水平依赖激活可对反社会人格障碍患者说谎和说真话行为进行识别,但是血氧水平依赖激活差异会随着善于说谎程度的增加而降低,这对测谎精确度提出了挑战.
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