目的：探讨sTn与子宫内膜癌的关系，以及两种检测方法在子宫内膜癌血清学诊断中的价值。方法：选用100例子宫内膜癌患者为研究组，以42例健康非孕妇女、15例妊娠妇女、43例其他妇科良性疾病妇女作为对照组，利用两种方法(3P9和4A6联合法及B72.3和CC49联合法)对两组患者血清中sTn水平进行检测。结果：子宫内膜癌组血清sTn水平及其阳性率均明显高于对照组(P<0.05)。妊娠妇女的血清sTn水平较高。随子宫内膜癌临床分期的增加，sTn抗原水平及检出阳性率也增加。3P9法在检测的敏感性、特异性、阳性预测值、阴性预测值、诊断准确性方面均高于B72.3法。结论：sTn有望成为子宫内膜癌的新型血清学诊断标志物，筛查时应将妊娠患者排除在外；3P9法优于B72.3法。%Objective:To investigate the relationship between tumor-associated carbohydrate antigen sTn and endometrial carcinoma, and to evaluate the diagnostic value of 2 test methods.Methods:A total of 200 patients were enrolled, including 100 subjects with endometrial carcinoma, 42 healthy nonpregnant women, 15 pregnant women without complications, and 43 patients with benign gynecologic diseases. hTe serum sTn-antigen concentrations were determined by 2 test methods (3P9 combined with 4A6, and B72.3 combined with CC49). n Results:hTere was a signiifcant difference in the value and the positive rate of sTn in the serum between the subjects and the contrasts (P<0.05). hTe sTn level in the pregnant women was high. hTe sTn level in the serum and its positive rate in endometrial carcinoma became higher with the clinical stage. 3P9 combined with 4A6 was better than B72.3 combined with CC49 in the detection of sTn in the serum as to sensitivity, specificity, positive-prediction, negative-prediction, and accuracy. n Conclusion:The sTn antigen may become a new serological marker for the diagnosis of endometrial carcinoma, but pregnant women should be excluded. 3P9 combined with 4A6 is better than B72.3 combined with CC49 in the detection of sTn in the serum.
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