血清CXCL16浓度与脑卒中患者颈动脉粥样硬化的相关性研究

摘要

目的 探讨血清CXCL16浓度与脑卒中患者颈动脉粥样硬化的关系.方法 对135名急性动脉粥样硬化性脑卒中患者行颈部血管超声检查,根据颈动脉内-中膜厚度( intima-median thickness,IMT )分为IMT增厚组和IMT正常组；根据斑块情况分为无斑块组、稳定斑块组和不稳定斑块组；根据斑块面积(carotid plaque area,CPA)四分位数间距分为4组,同时应用ELISA方法检测其血清CXCL16浓度,并进行组间比较.结果 血清CXCL16浓度与IMT增厚、不稳定斑块和高CPA密切相关,Logistic回归结果显示高血清CXCL16浓度是IMT增厚、不稳定斑块和高CPA的独立危险因素(P=0.021,P=0.003.P=0.005).结论 CXCL16是脑卒中患者颈动脉粥样硬化的独立危险因素,检测血清CXCL16浓度可能成为发现早期动脉硬化的方法.%Objective To study association between serum CXCL16 levels and carotid atherosclerosis in patients with stroke. Methods A total of 135 cases with acute atherosclerotic stroke were examined using ultrasound to evaluate their carotid atherosclerotic lesions, the patients were then divided into normal(intima-median thickness, IMT) and increased IMT group, without plaque, stable plaque and vulnerable plaque group, 4 groups according to carotid plaque area(CPA) quartiles. Results Serum CXCL16 levels were closely associated with increased IMT, vulnerable plaque and increased CPA, logistic analysis showed that increased serum CXCL16 levels was independent risk factor of increased IMT, vulnerable plaque and increased CPA. Conclusion CXCL16 is an independent risk factor of carotid atherosclerosis in stroke, detection of it may be a new way to find early atherosclerosis.