circRNAs作为胃癌诊断标记物可行性的 meta 分析✲

摘要

Objective: To evaluate the value of circular RNAs ( circRNAs) as diagnostic biomarkers for gastric cancer. Methods: We searched relevant articles, published from January 2015 to November 2018, from PubMed, Web of Science, Wanfang Database and CNKI Database. The rationality of each study was assessed by QUADAS-2, a revised tool for the quality assessment of diagnostic accuracy studies. STATA (version 15. 0) was used to evaluate the diagnostic value of circR-NAs for gastric cancer and publication bias. Results: This meta-analysis included 1394 patients from 13 articles. Pooled sensitivity, pooled specificity, pooled positive likelihood ratios, pooled negative likelihood ratios, and pooled diagnostic odds ratio were 0. 70 (95% CI: 0. 66－0. 75), 0. 72 (95% CI: 0. 68－0. 75), 2. 50 (95% CI: 2. 20－2. 80), 0. 41 (95% CI: 0. 36－0. 48), 6. 00 (95% CI: 5. 00－8. 00), respectively, and area under the curve ( AUC) was 0. 77. CircRNAs hsa_circ_00001649 (AUC: 0. 83) and hsa_circ_0000096 (AUC:0,82) were more diagnostically effective. Conclusion: Cir-cRNAs might be suitable for diagnostic biomarkers of gastric cancer.%目的:评价环状RNAs作为胃癌诊断标记物的价值.方法:检索PubMed、Web of science外文数据库和中国知网、万方中文数据库2015年1月至2018年11月之间发表的相关文献,应用诊断试验质量评价系统( QUADAS-2)对每项研究方法合理性进行评价,采用Stata 15. 0软件分析环状RNAs与胃癌诊断相关性以评估诊断价值,采用sta-ta15. 0软件分析参考文献是否存在发表偏倚.结果:13篇参考文献纳入研究,包含1 394名患者.环状RNAs作为胃癌诊断标记物的合并敏感度是0. 70(95% CI: 0. 66～0. 75),合并特异度是0. 72(95% CI: 0. 68～0. 75),合并阳性似然比2. 5(95% CI: 2. 2～2. 8),合并阴性似然比0. 41(95% CI: 0. 36～0. 48),合并诊断优势比是6(95% CI: 5～8),曲线下面积(area under the curve,AUC)0. 77(95% CI: 0. 73～0. 80),其中环状RNA Hsa_ circ_00001649( AUC:0,83)和hsa_circ_ 0000096(AUC:0. 82)表现出了较高的诊断效率.结论:环状RNAs具有作为胃癌诊断标记物的潜力.