Objective: To analyse the variation trends of hepatocellular carcinoma mortality rates during 1968～2009 in Haimen, Jiangsu, so as to provide the evidence for policy making. Methods: Based on the routine data of hepatocellular carcinoma mortality and demographic data , mortality rate and age specific mortality rate were calculated and analyzed by SPSS14. 0 software. The diseases were classfied by standard ICD-9 International Classification of Diseases ( After 2002 , according to ICD-IO ). Results : The mortality rate of liver cancer rose from 30. 17/100 000 in 1968 to 74. 45/100 000 in 1990 in Haimen. The average annual growth rate was 4. 01％ from 1968 to 1990. The mortality rate fell to 46. 87/100 000 in 1996. The average annual growth rate was - 6. 40％ from 1990 to 1996. The mortality rate rose to 60. 82/100 000 in 2003. The average annual growth rate was 3. 31％ from 1996 to 2003. The mortality rate was 49. 43/100 000 in 2009. The average annual growth rate was - 2. 92％ from 2003 to 2009. Liver cancer mortality of male was significantly higher than that of female. The first peak age of the liver cancer mortality was 45 years old in Haimen residents in 1989 and 1992. The first peak in 1998 occured in 50 years old group, in 55 years old group in 2005. It delayed 2 age group in 2005 than in 1989、1992 and 1998. Though the first peak appeared in 50 years old group in 2009 , but it was obviously lower than a few years before. The male age specific mortality trends of liver cancer resembled that of the residents in Haimen. Female first peak age of the liver cancer age-specific mortality was in 60 years old group in 1989 and 1992. It appeared in 70 years old group in 1998. Although the first peak appeared in 60 groups in 2005 and 2009. it was obviously lower than that in 1989, 1992 and 1998. Female liver cancer mortality rose gradually with age. The first peak age of liver cancer delayed 1 - 2 age group in 2009 than in 1998 and the mortality was alsoreduced. Conclusion : Liver cancer mortality of Haimen residents hasdeclined since 1991. The death peak age is delayed.%目的:分析1968年～2009年江苏省海门市肝癌死亡率变化趋势,为肝癌的防治决策制定提供参考.方法:根据海门市1968年～2009年的肝癌死亡资料以及历年人口资料,采用SPSS14.0软件分析肝癌死亡率、标化死亡率和年龄别死亡率.结果:海门市肝癌死亡率由1968年的30.17/10万上升到最高峰1990年的74.45/10万,年平均增速为4.01%;1996年降至46.87/10万,1990年～1996年的年平均增速为-6.40%;2003年又上升到60.82/10万,1996年～2003年的年平均增速为3.31%;以后逐年下降到2009年的49.43/10万,2003年～2009年平均增速为-2.92%.男性肝癌死亡率明显高于女性.海门市居民肝癌死亡率1989年和1992年第一次高峰为45岁组,1998年第一次高峰为50岁,2005年第一次高峰出现在55岁组,与前3 个年份比推迟了2个年龄组,2009年虽第一次高峰出现在50岁组,但明显低于前几个年份.男性肝癌死亡率的年龄别变化基本类似于海门市居民总死亡率变化趋势.女性肝癌年龄别死亡率1989年和1992年第一次高峰出现在60岁组,1998年第一次高峰出现在70岁组,2005年和2009年第一次高峰虽仍为60岁组,但明显低于1989年、1992年和1998年,女性肝癌死亡率随年龄组逐渐上升.2009年与1998年比,肝癌死亡的首次高峰年龄推迟了1～2年龄组,死亡率也相应下降了.结论:海门市居民肝癌死亡率自1991年开始呈下降趋势,肝癌死亡高峰年龄在后移.
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