目的：采用3．0T MRI 对正常志愿者脑体积进行定量测量，确定正常值参考范围，并探讨其与年龄和性别的相关性。方法采用CE Signa EXCITE 3．0T高分辨MRI对140例健康志愿者（男性73例，女性67例，年龄10～84岁，平均45．8±18．3）进行头颅MRI 3DT1成像，在AW4．2工作站上采用半自动方法计算脑体积。并对不同性别、年龄进行统计分析。结果脑体积95％可信区间：男性为1480．15±141．04cm 3，女性为1322．91±110．11cm 3。脑体积与性别间差异有统计学意义（p＜0．05），男性的脑体积要大于女性。脑体积在各年龄段之间差异无统计学意义（ p＞0．05）。结论头颅MRI 3D可以提供更准确的大脑容积定量，为各种相关疾病的临床诊断和治疗方案的制定提供客观依据。%Objective To measure the brain volume in normal Chinese , try to explore the relationship Methods 140 volunteers were examined with 3D T1 weighted images to obtain the between that with gender and age . whole brain image .The volume of whole brain was calculated on AW 4.1 workstation in semi-auto manner .Data of whole brain volume were analyzed in different gender and age with test and variance analysis .Results Volumes of the whole brain (The 95%confidence interval) were 1480.15±141.04 cm3 for male and 1322.91±110.11cm3 for . There was significant statistical correlation between whole brain volume and gender ( p<0.05) , the whole brain volume in male was larger than that in female .The correlation analysis indicated that negative correlation exist between age and whole brain volume (p<0.01).ANOVA analysis showed there was no significant correlation between the whole brain volume and age groups (P>0.05).Conclusion Whole brain MRI3D can provide quantitative brain volume more accurately , and provide objective basis for clinical diagnosis and treatment of various diseases .
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