Objective To investigated the association between plasma viscosity(PV)and acute ischemic stroke and compare the difference of plasma viscosity in patients with different ischemic stroke subtypes. Methods A total of 120 patients with acute ischemic stroke from Hebei general hospital were consecutively enrolled into large artery atherosclerosis group(n = 44), small artery occlusion group(n = 40)and cardioembolic group(n = 36) during 2013-2014. The study variable is plasma viscosity. Results Patients with acute ischemic stroke showed increased PV(stroke:1.36[1.35-1.38])compared to patients without ischemic stroke(1.32[1.27-1.34], P < 0.05). The group of small artery occlusion had a significantly higher mean values of PV(1.42[1.39-1.45])compared to those of largevessel atherosclerosis group(1.33[1.31-1.35])or cardioembolic group(1.35[1.33-1.37], P <0.05). Higher PV levels are associated with the presence of ischemic stroke with small artery occlusion(OR=6.33). Conclusion PV in patients with acute ischemic stroke is increased. Higher PV levels are associated with the presence of ischemic stroke with small artery occlusion. Plasma viscosity may participate in the complex pathophysiology of ischemic stroke with small artery occlusion.%目的：研究血浆粘度（PV）与急性脑梗死及不同卒中亚型之间的关系。方法收集2013年8月至2014年8月在河北省人民医院院神经内科被诊断为急性脑梗死的住院患者，入选120例，分为大动脉粥样硬化组（n =44）、小动脉闭塞组（n =40）、心源性脑栓塞组（n =36），以血浆粘度作为研究变量。结果分析发现急性脑梗死患者血浆粘度[1.36（1.35~1.38）]和无缺血性卒中患者的血浆粘度[1.32（1.27~1.34）]相比显著增高（P <0.05）。小动脉闭塞型卒中患者的血浆粘度[1.42（1.39~1.45）]和大动脉粥样硬化组[1.33（1.31~1.35）]以及心源性脑栓塞组[1.35（1.33~1.37）]相比显著增高（P <0.05）。而且血浆粘度的增高与小动脉闭塞型脑梗死的发生密切相关（OR=6.33）。结论急性缺血性卒中患者血浆粘度明显增高且血浆粘度增高与小动脉闭塞型脑梗死密切相关，可能在小动脉闭塞型脑梗死发生和发展中发挥重要作用。
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