目的 探讨血浆黏度与脑白质疏松(LA)之间的相关性.方法 选取正常对照组60例和LA组60例,收集2组的临床资料来评估LA相关可能的危险因素,进一步对血浆黏度进行多因素Logistic回归分析,并采用MRI的Fazekas方法对LA组进行分级,评估不同程度LA患者的血浆黏度水平差异.结果 LA组的年龄、三酰甘油及血浆黏度水平与对照组比较,差异有统计学意义(P＜0.05),血浆黏度的增高与LA的发生相关(OR=1.298),当调整其他危险因素后,差异仍有统计学意义(P＜0.05);且随着Fazekas评分增加,血浆黏度水平随之增加.结论 血浆黏度水平和LA相关,可能是LA的独立危险因素,且随着LA程度的加重而增高.%Objective To investigate the association between plasma viscosity and leukoaraiosis(LA). Method A total of sixty people were chosen for control group, and sixty people were chosen as LA group. The clinical data were compared to estimate the associated possible risks of LA in sixty patients with LA and sixty patients of control group. The multi-factor Logistic regression analysis of plasma viscosity was carried out. Fazekas grading of LA were evaluated by MRI to analyze the plasma viscosity level in different degree of LA. Results Compared with control group, the difference of age, total triacylglycerol and plasma viscosity level in the LA group was statistically significant (P＜0.05). Higher level of plasma viscosity was associated with LA (OR=1.298). The difference was statistically significant after adjustment for other risk factors associated with LA (P＜0.05). The plasma viscosity level increased with increased Fazekas scores in LA. Conclusion Plasma viscosity level was closely associated with LA, and might be an independent risk factor for LA. The level of plasma viscosity increased with the severity of LA.
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