人源醛酮还原酶AKR7 A与疾病关系研究进展

摘要

醛酮还原酶超家族( aldo keto reductase superfamily,AKRs)在生物界分布广泛,参与体内醛酮类化合物的清除代谢,使醛或酮上的羰基转化成醇,其活性与多种疾病的发生发展密切相关。 AKR7A是一种在生物活化( bioaeti-vation)及生物解毒(biodetoxifieation)中起到重要作用的酶。 AKR7A家族中表达于人体的有AKR7A2和AKR7A3,主要就关于它们的研究进展进行综述。%AKRs are widely distributed in nature,participates in the clear metabolism in the body and make the aldehyde or ketone carbonyl convert into alcohol, and their activityies are closely related to a wide variety of tumor. AKR7A is an enzyme,plays an impor-tant role in bioaetivation and biodetoxifieation. AKR7A2 and AKR7A3 are two members of AKR7 and express in human body. This arti-cle mainly reviewed the progress of the research.