慢性乙型肝炎患者血清铁、镁、铜、锌检测及相关分析

摘要

Objective:To observe the changes of serum Fe3+,Mg2+,Cu2+ and Zn2+levels in patients with chronic hepatitis B.Methods:Colorimetric method was used to measure the contents of serum Fe3+,Mg2+,Cu2+ and Zn2+ in 126 patients with chronic hepatitis B and 130 healthy controls.Results:The serum levels of Fe3+,Mg2+ and Zn2+ in patients with chronic hepatitis B were significantly lower than those in the healthy controls(P＜0.01).In contrast,the serum Cu2+ level in patients with chronic hepatitis B was significantly higher than that in the healthy controls(P＜0.01).The patients were divided into young-age,middle-age and old-age groups.The results indicate that the serum levels of Fe3+,Mg2+ and Zn2+ in the three groups were all lower than those in the controls(P＜0.01),but the serum Cu2+ level was higher than that in the controls(P＜0.01).Conclusions:Determination of serum Fe3+,Mg2+,Cu2+ and Zn2+ levels is of clinical significance in patients with chronic hepatitis B.It is also useful as a predictor of prognosis.%目的：探讨慢性乙型肝炎(慢乙肝)患者血清中各年龄组Fe3+、Mg2+、Cu2+、Zn2+的含量变化。方法：用比色法检测126例慢乙肝患者及130名健康者血清Fe3+、Mg2+、Cu2+、Zn2+。结果：126例慢乙肝患者的Fe3+、Mg2+、Cu2+、Zn2+与130名健康者的含量进行比较，前者的Fe3+、Mg2+、Zn2+显著低于后者(P＜0.01)；而前者的Cu2+显著高于后者(P＜0.01)。根据年龄分组把126例分为青、中、老三组，结果显示各年龄组患者的Fe3+、Mg2+和Zn2+含量均较对照组低(P＜0.01)，而Cu2+则均高于对照组(P＜0.01)。结论：检测血清Fe3+、Mg2+、Cu2+、Zn2+的含量，有助于慢乙肝的诊断及治疗，并可随时对患者进行动态的预后评价。