有偿献血员人类免疫缺陷病毒合并乙型、丙型肝炎病毒感染及生化指标分析

摘要

Objective: To explore the changes of liver and kidney function indicators in human immunodeficiency virus( HIV ) infected blood donors co-infected with hepatitis C virus( HCV ) or hepatitis B virus( HBV ). Methods:The serological markers of HCV and HBV, and all indicators of liver and kidney were detected among 125 HIV infected blood donors and 40 health cases as control.Results:The infection rate of HCV was 92.0％ and 5.6％ of HBV among 125 HIV infected blood donors. There were statistical differences of ALT, AST between HIV co-infected with HCV donors and health control cases, also with HIV infected alone donors. In contrast to health control group,there was significant difference of β2-MG in HIV co-infected with HBV or HCV and HIV infected alone donors. There was significant difference of β2-MG between HIV co-infected with HCV and HIV infected alone donors( P ＜ 0.01 ).Conclusions:HIV co-infected with HBV or HCV may accentuate the damage of liver function, and it seems no effect on kidney function. The rise of β2-MG may be the over-activation of host immunity.%目的:探讨有偿献血员中人类免疫缺陷病毒(HIV)合并乙型、丙型肝炎病毒(HCV、HBV)感染情况及其肝、肾功能指标的变化.方法:选取125例曾有偿献血HIV感染者,进行HCV、HBV血清学标志物及肝、肾功能各项指标检测.结果:125例中,合并HCV感染率为92.0%,合并HBV感染率为5.6%,合并HCV感染组AST、ALT与对照组和单纯HIV感染组差异均有统计学意义.HIV合并HCV、HBV感染组及单纯HIV感染组β2微球蛋白与对照组差异有统计学意义,合并HCV组与单纯HIV感染组β2微球蛋白差异有统计学意义(P<0.01).结论:HIV合并HCV可加重HIV患者的肝脏损害,对肾功能未造成影响,β2微球蛋白升高可能是机体免疫过度活化的表现.