静脉水化疗法预防经皮冠状动脉介入术后造影剂肾病

摘要

目的:探讨静脉水化疗法预防经皮冠状动脉介入术(PCI)后造影剂肾病(CIN)的预防作用.方法:选择PCI患者180例,采用非随机分组观察,将观察对象分为强化饮水组(对照组)86例和静脉水化组(静脉组)94例,比较2组术前、术后血清肌酐(SCr)、尿素氮(BUN)、血β2微球蛋白(β2-mG)、尿β2-mG等结果.结果:静脉组术后SCr、BUN、β2-mG及尿β2-mG均明显低于对照组(P＜0.01);静脉组术后发生CIN 3例,对照组术后CIN 10例,2组差异有统计学意义(P＜0.05).结论:与术后48 h不限制饮水的水化方法比较,通过静脉注射等渗氯化钠溶液进行水化可以预防肾功能损伤,并有效减少术后急性肾衰竭的发生.%Objective:To investigate the effect of intravenous hydration therapy in prevention of contrast-induced nephropathy(CIN) after percutaneous coronary intervention(PCI). Methods:One hundred and eighty cases of patients were divided into the control group ( drinking water) and experimental group ( intravenous hydration therapy). The levels of serum creatinine ( SCr), urea nitrogen ( BUN ),serum β2-microglobulin( β2-mG), and urinary β2-mG were compared between the two groups after PCI. Results:The levels of SCr,BUN, β2 -mG, and urinary β2-mG were significantly lower in experimental group ( n= 94 ) than that in control group ( n= 86 ) ( P ＜ 0.01 ); CIN occurred in 3 cases of experimental group, but 10 cases of control group (P ＜ 0.05 ). Conclusions:Intravenous hydration therapy can prevent the injury of kidney function and reduce the incidence of acute renal failure after PCI.