Survivin在宫颈癌及癌前病变组织中的表达及意义

摘要

Objective:To investigate the application value of Survivin expression in the diagnosis of cervical cancer and precancerous lesions by in situ hybridization. Methods:The Survivin expressions in 45 tissue samples of cervical cancer ( observation group ) , 45 tissue samples of cervical intraepithelial neoplasia(control group 1) and 45 normal cervical tissue samples(control group 2) were detected by in situ hybridization. Results:The positive rates of Survivin expression in control group 2,control 1 group and observation group were 2. 2%,48. 9% and 84. 4%,respectively,the differences of which were statistically significant(P0. 05). Conclusions:Survivin plays certain role in the occurrence and development of cervical cancer and precancerous lesions,which can be used as a sign of poor prognosis.%目的：探讨Survivin原位杂交表达在宫颈癌及癌前病变诊断中的应用效果。方法：选取45例宫颈癌患者病理组织为观察组，宫颈上皮内瘤变组织45例为对照1组，正常宫颈组织45例为对照2组。入试者均行Survivin原位杂交检测。结果：Survivin在对照2组、对照1组、观察组阳性率分别为2.2%、48.9%和84.4%，差异均有统计学意义(P0.05)。结论：Suvrvini在宫颈癌及癌前病变的发生发展中发挥一定作用，可作为宫颈癌预后不良的标志之一。