急性ST段抬高型心肌梗死PCI术后使用双倍剂量氯吡格雷的效果观察

摘要

Objective:To explore the anti-platelet effects and safety of double dose of clopidogrel in acute ST-segment elevation myocardial infarction patients after percutaneous coronary intervention(PCI). Methods:Eighty acute ST-segment elevation myocardial infarction patients with PCI were randomly divided into the treatment group and control group(40 cases each group). The control group were treated with 100 mg aspirin and 75 mg clopidogrel once a day by oral. The treatment group were treated with 100 mg aspirin once a day and 75 mg clopidogrel twice a day for 1 month,then changed to 75 mg clopidogrel once a day by oral. After a month of treatment, the platelet aggregation rates in two groups were observed. The incidence of cardiovascular events in two groups were analyzed after 1 year of following up. Results:The difference of the platelet aggregation rate between two groups after 1 month of treatment was statistically significant(P 0. 05). Conclusions:The treatment of acute ST-segment elevation myocardial infarction patients PCI with double dose of clopidogrel can decrease the cardiovascular events.%目的：：探讨急性ST段抬高型心肌梗死患者经皮冠状动脉介入( PCI)术后口服双倍剂量氯吡格雷抗血小板的疗效。方法：80例患者PCI术后随机分为观察组和对照组各40例。对照组口服阿司匹林100 mg,氯吡格雷75 mg,每天各1次；观察组口服阿司匹林100 mg,每天1次,氯吡格雷75 mg,每天2次,1个月后改为氯吡格雷75 mg,每天1次。服药1个月后,观察2组血小板聚集率变化,随访1年后主要心血管事件的发生情况。结果：与对照组比较,观察组服药1个月后血小板聚集率变化差异有统计学意义(P0.05)。结论：急性ST段抬高型心肌梗死患者PCI术后口服双倍剂量氯吡格雷能够降低术后主要心血管事件的发生。