帕金森病人血清分化型胚胎软骨表达基因1和肝X受体β水平的相关性研究

摘要

目的:探讨帕金森病(PD)病人血清中分化型胚胎软骨表达基因1(DEC1)和肝X受体β(LXRβ)水平及二者相关性.方法:选择PD病人50例(PD组),选择同期健康人群50名为对照(对照组).检测2组受试者血清DEC1、LXRβ水平.结果:PD组血清DEC1水平明显高于对照组(P0.05);年龄≥60岁PD病人的LXRβ水平低于0.05).The serum level of LXRβ in more than or equal to 60 years old PD patients was lower than that in less than 60 years old PD patients(P<0.05).The serum levels of DEC1 and LXRβ in PD patients with cognitive dysfunction were significantly higher and lower than those in PD patients without cognitive dysfunction,respectively(P<0.01).With the deterioration of PD patients,the serum levels of DEC1 and LXRβ gradually increased and decreased,respectively(P<0.05 to P<0.01).The serum level of DEC1 was negatively correlated with the level of LXRβ in PD patients(r= -0.326,P<0.05).Conclusions:The serum level of DEC1 is negatively correlated with the level of LXRβ in PD patients,which may be involved in the onset and progression of PD.