丁苯酞软胶囊治疗脑小血管病伴认知功能损害病人的临床疗效及对血流灌注的影响

摘要

目的:探讨丁苯酞软胶囊治疗脑小血管病病人认知功能损害的临床疗效及对血流灌注的影响.方法:选取脑小血管病病人120例,按照随机数字法分为观察组和对照组,每组60例,对照组给予常规降压、调脂、改善循环等治疗,观察组在对照组基础上给予丁苯酞治疗,疗程均为1个月,观察治疗前后简易精神状态检查量表(MMSE)及蒙特利尔量表(MOCA)评分,并对所有病人治疗前后进行64排螺旋CT灌注成像检查,计算血流灌注参数值变化.结果:治疗前,2组MMSE和MOCA评分比较差异均无统计学意义(P>0.05),治疗后2组MMSE及MOCA评分均较治疗前显著升高(P0.05),治疗后2组血流速度、脑血流量及平均通过时间均较治疗前显著改善(P0. 05),the MMSE and MOCA scores in two groups after treatment significantly increased, and the increasing degree of which in observation group was more obvious. Before treatment, the differences of blood flow velocity, cerebral blood volume and mean transition time between two groups were not statistically significant(P>0. 05),the blood flow velocity, cerebral blood volume and mean transition time in two groups after treatment significantly improved(P<0. 05 to P<0. 01),and the improving degree of which in observation group was more obvious(P<0. 01). Conclusions:Butylphthalide soft capsule can improve the cognitive function and increase the blood flow of lesions,which is safe and effective,and worthy of clinical promotion.