Effects of Bright Light Therapy of Sleep, Cognition, Brain Function, and Neurochemistry in Mild Traumatic Brain Injury.

摘要

Data collection is currently underway and preliminary findings from the first subjects to complete the study are encouraging. Overall, our preliminary data on cognition, emotion, subjective and objective sleep quality suggest that six weeks of morning Bright Blue Light therapy versus comparable Amber Light Placebo are supporting our initial hypotheses. Furthermore, initial comparisons using functional magnetic resonance imaging tasks also suggest that the Bright Blue Light condition was effective in altering brain responses during demanding attention and concentration tasks, whereas such changes were not evident in the Amber Light Placebo condition. While data are too limited to draw conclusions, these initial findings point toward some beneficial effects of the active treatment in reducing daytime sleepiness and sleep-related functional impairments, improving objective sleep quantity, and showing clinically significant improvements in several neuropsychological domains, as well as affecting functional brain responses.