针刺、米非司酮、米索前列醇抗早孕作用比较的实验研究

摘要

In order to study the mechanism of acupuncture and drugs against early pregnancy, the rat early pregnancy model and an indirect intrauterine pressure recording method were used, with the frequency and intensity of the uterine contraction as experimental criteria for evaluating the changes in uterine contraction. By doing so, the changes in the intrauterine pressure and uterine contraction could be scientifically, simply, sensitively and objectively recorded. The results showed that the intensity of uterine contraction was reinforced by mifepristone and misoprostol used in combination; and the random uterine contraction was effectively inhibited and the effective uterine contraction was strengthened by acupuncture. The results can help the clinical practice of treating early pregnancy.%米非司酮及米索前列醇作为临床常用的抗早孕药物，流产效果较好。在中医的“血衰气旺定无妊，血旺气衰应有体”，泻三阴交，补合谷是在“血衰气旺也"，补三阴交，泻合谷是“血旺气衰矣"的理论指导下，许多学者观察了针刺合谷、三阴交的堕胎作用。为探讨针刺、药物抗早孕的作用机制，我们采用早孕大鼠模型，建立间接反映子宫内压的记录方法，安放电极记录子宫收缩频率、强度作为判断宫缩变化的指标，科学、简便、灵敏、客观地记录宫内压变化及子宫收缩情况。结果表明，两药配伍可明显增强子宫收缩力，针刺可有效抑制子宫无序收缩，增强子宫的有效收缩能力，从而为临床治疗提供了客观依据。