不同强度按压背俞穴对CFS大鼠行为学及体重的影响

摘要

目的 探讨不同强度穴位刺激对慢性疲劳综合征(CFS)大鼠行为学及体重的影响.方法 将60只SD大鼠随机分为轻压组、中压组、重压组、抚摸组、模型组和空白对照组,采用剥夺睡眠和力竭游泳制作CFS模型,动态观测不同阶段各组大鼠行为表现和体重的变化.结果 4周的剥夺睡眠和力竭游泳导致大鼠行为学和体重发生变化,基本符合CFS的临床表现.按压背俞穴对实验模型各组大鼠行为学和体重有一定调节作用,轻压组和抚摸组作用最佳.结论 剥夺睡眠和力竭游泳可能是制作CFS动物模型的有效方式之一.适度的穴位刺激一定程度上可改善CFS实验动物模型症状,对针灸推拿临床治疗CFS有一定借鉴意义.%Objectives To investigate the influences of acupoint stimulation with different intensities on the ethology and body weight in rats with chronic fatigue syndrome (CFS). Methods All SD rats (n = 60) were randomly divided into the low-pressure group, mid-pressure group, high-pressure group, stroking group, model group and blank group. The CFS model was established by using the method of sleep deprivation and exhausting swimming. The changes of behavior and body weight were dynamically observed at different stages in rats of all groups. Results The method of sleep deprivation and exhausting swimming for 4 weeks had induced the changes of behavior and body weight in rats, which was accorded with the manifestations of CFS. Pressing Back-Shu points had some regulative effects on the behavior and body weight in rats of all test groups, which was more significant in the low-pressure group and stroking group. Conclusion The method of sleep deprivation and exhausting swimming may be one of effective methods for establishing animal CFS model. Moderate stimulation on acupoints can relieve the symptoms in CFS model to a certain extent, which may be a reference for the treatment of CFS with acupuncture.