COED-B方案和CHOP方案治疗非霍奇金淋巴瘤的临床比较观察

摘要

目的 比较分析COED-B方案和传统CHOP方案治疗非霍奇金淋巴瘤的疗效.方法 84例非霍奇金淋巴瘤患者随机分为COED-B组和CHOP组,COED-B组患者采取COED-B方案化疗,CHOP组患者采取传统CHOP方案化疗,比较分析治疗效果、不良反应以及生存期.结果 COED-B组治疗总有效率(88.1%)显著高于CHOP组(59.5%),差异有统计学意义(P<0.05).2组患者常见不良反应包括贫血、胃肠道反应、靶细胞降低、脱发等,发生率比较差异均无统计学意义(P均>0.05).COED-B组1 a生存率显著高于CHOP组,差异有统计学意义(P<0.05);2组患者3、5 a生存率比较差异均无统计学意义(P均>0.05).COED-B组患者中位无疾病进展时间(6.8个月)显著短于CHOP组(10.4个月),差异有统计学意义(P<0.05).结论 COED-B方案能够提高非霍奇金淋巴瘤的疗效,具有高效、低毒、经济的特性,对基层医院治疗非霍奇金淋巴瘤有重要意义.%Objective To compare the clinical efficacy of COED-B regimen and traditional CHOP regimen in the treatment of non-Hodgkin lymphoma.Methods Eighty-four patients with non-Hodgkin lymphoma were divided into the COED-B group and the CHOP group,the patients in the COED-B group were taken treatment of COED-B regimen chemotherapy,the patients in the CHOP group were taken treatment of CHOP regimen chemotherapy,the therapeutic effect,toxicities and survival of the patients were compared between the two groups.Results The total efficiency rate (88.1%) in the COED-B group was significantly higher than that in the CHOP group (59.5%) (P<0.05).The common toxicities of two groups included anemia,gastrointestinal reactions,reducing the target cells and alopecia.The toxicity incidences was no significant difference between the two groups (P>0.05).The 1-year survival rate in the COED-B group was significantly higher than that in the CHOP group (P<0.05);the 3-,5-year survival rates were no significant difference between the two groups (P>0.05).The median progression free time (6.8 months)in the COED-B group was significantly shorter than that in the CHOP group (10.4 months) (P<0.05).Conclusion COED-B regimen can improve the total efficiency of non-Hodgkin lymphoma,which is effective,low toxicity and economy.