鼻内镜下行鼻腔冲洗对鼻咽癌放疗患者疗效观察

摘要

Objective :To observe the effect of nasal irrigation under the nasal endoscope on the patients with nasopharyngeal carcino‐ma treated with radiotherapy .Methods:120 patients with nasopharyngeal carcinoma treated with radiotherapy were chosen from January 2012 to April 2014 in our hospital and randomly divided into the control group and the observation group ,with 60 patients in each group . Nasal irrigation was used in all the patients .Normal saline was used in the control group twice a day ;the observation group was treated further with nasal irrigation under the nasal endoscope once a week .The visual analogue scale (VAS) scores before and after the treat‐ment ,the effective ratio of the treatment ,and the incidence of complications were compared between the two groups .Results :After the treatment ,the VAS scores of the two groups were both decreased compared with those before the treatment ,and the VAS scores of the observation group were decreased more significantly than those of the control group ,the differences being statistically significant (P<0 . 01);Before the treatment ,the incidence of complications of the observation group and the control group were 83 .3% and 80 .0% respec‐tively .After the treatment ,the incidence of complications of the observation group and the control group were decreased to 35% and 50% respectively ,the differences being statistically significant (P<0 .01) .Conclusion:Nasal irrigation under the nasal endoscope can sig‐nificantly reduce the side effects caused by radiotherapy and improve the environment of nasal cavity ,patients'comfort level and the qual‐ity of life after radiotherapy .It's worthy of the clinical application in the treatment of the patients with nasopharyngeal carcinoma .%目的：观察鼻内镜下行鼻腔冲洗对鼻咽癌放疗患者的疗效。方法：选取2012年1月至2014年4月进行放疗的120例鼻咽癌患者，随机分为对照组和观察组，每组各60例。所有患者进行鼻腔冲洗，对照组患者采用生理盐水冲洗，2次／d ，观察组患者在此基础上采用鼻内镜下行鼻腔冲洗，1次／周。比较两组患者治疗前后视觉模拟量表（visual clualogue scale ，VAS）评分、治疗有效率以及放疗并发症发生率。结果：治疗后，两组患者 VAS评分均明显低于治疗前（ P ＜0．01），两组间比较，观察组 VAS评分明显低于对照组（ P ＜0． 01）；观察组患者治疗有效率明显高于对照组，组间比较，差异具有统计学意义（ P ＜ 0．01）；治疗前，观察组和对照组患者放疗并发症的发生率分别为83．3％和80．0％，治疗后，观察组和对照组患者放疗并发症的发生率分别降低至35％和50％，比较两组患者治疗后放疗并发症的发生率，差异具有统计学意义（ P ＜0．01）。结论：鼻内镜下行鼻腔冲洗能够明显减少放疗导致的不良反应，有效改善鼻腔内环境，提高患者舒适度以及放疗治疗后的生存质量，可推广用于鼻咽癌患者的临床治疗。