刺五加注射液对大鼠坐骨神经损伤修复的影响

摘要

目的：探讨刺五加注射液对大鼠坐骨神经损伤修复的影响。方法：将60只 SD雄性大鼠随机分为3组，分别为对照组、模型组和刺五加组，每组20只。对照组不施加任何干预，模型组和刺五加组进行左侧坐骨神经离断后缝合。术后刺五加组每日给予刺五加注射液腹腔注射（20 mg／kg），其余两组常规喂养。观察三组大鼠左足皮肤温度、坐骨神经功能指数（seiatic fanetion index ，SFI）和坐骨神经传导速度（sciatic nerve conduction velocity ，SNCV）。结果：在术后第3周和第4周，刺五加组大鼠左后足部皮肤温度均比模型组明显升高（ P ＜0．01）；术后第2周、第4周和第6周，刺五加组坐骨神经功能指数均明显优于模型组（ P ＜0．01）；术后第2周、第4周和第6周，刺五加组坐骨神经功能指数均明显优于模型组（ P ＜0．01）。结论：刺五加注射液对大鼠周围神经损伤后功能恢复具有促进作用。%Objective :To explore the effect of acanthopanax senticosus injection on the repair of sciatic nerve injury in rats .Methods:60 SD rats were randomly divided into 3 groups (the control group ,the model group ,and the acanthopanax senticosus group) ,20 rats in each group .The rats in the control group were not given any intervention .All the left sciatic nerves were sutured after being cut in the other two groups .The rats in acanthopanax senticosus group were given daily intraperitoneal injection of acanthopanax senticosus (20mg/kg) ,and the rats in the control group and the model group were given normal feeding ,with skin temperature in the left foot ,sciatic nerve function index (SFI) and sciatic nerve conduction velocity (SNCV ) of rats in all groups observed .Results :3 or 4 weeks after surgery , compared with the model group ,the left foot skin temperature in acanthopanax senticosus group increased significantly ( P <0 .01) .SFI of acanthopanax senticosus group was superior to that in the model group after 2 ,4 and 6 weeks of operation ( P <0 .01) .SNCV in acan‐thopanax senticosus group was better than that in the model group in postoperative 2 ,4 and 6 weeks ( P <0 .01) .Conclusion:Acantho‐panax senticosus injection has an obvious effect of promoting the regeneration of peripheral nerve injury in rats .