目的 探讨癫痫患者血清S100B蛋白浓度与认知功能的相关性.方法 对55例癫痫患者和33例健康对照者进行蒙特利尔认知功能量表 (MoCA) 测试, 癫痫组依据MoCA得分分为癫痫认知障碍组 (<26分) 和癫痫非认知障碍组 (≥26分) , 分别检测其血清S100B蛋白水平.结果 健康对照组、癫痫非认知障碍组、癫痫认知障碍组的S100B蛋白浓度依次升高 (P均<0. 05);癫痫认知障碍组S100B蛋白水平与延迟记忆 (r=-0. 270, P <0. 05) 和注意力 (r=-0. 353, P <0. 05) 得分呈负相关.结论 癫痫患者血清S100B蛋白水平高于健康人, 认知障碍的癫痫患者S100B水平与记忆力和注意力表现呈负相关.%Objective To explore the correlation between serum S100 B protein levels and cognitive function in epilepsy patients. Methods The Cognitive function of 55 patients with epilepsy and 33 healthy controls was tested by the Montreal Cognitive function scale (MoCA) . According to MoCA scores, the epilepsy patients were divided into cognitive impairment epileptic group (< 26 points) and non-cognitive impairment epileptic group (> 26 points) , then detect their serum S100 B protein levels. Results The concentration of S100 B protein in the group of healthy controls、non-cognitive impairment epileptic group and cognitive impairment epileptic group increased successively (all P < 0. 05) . Serum S100 B protein level was negatively correlated with the score of delayed memory (r =-0. 270, P < 0. 05) and attention (r =-0. 353, P < 0. 05) in cognitive impairment epileptic group. Conclusion The serum S100 B protein level of epileptic patients was higher than that of healthy people, and was negatively correlated with delayed memory and attention.
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