Objective To explore the correlation between serum uric acid and progressive supranuclear palsy ( PSP) .Methods 71 patients were selected as the PSP group ,70 healthy people as control group .The test was used to compare serum uric acid between PSP patients and controls .By comparing serum uric acid for different genders ,among sub-types of the PSP group with their counterparts in the control group .The relevance between serum uric acid and H-Y,UPDRSⅢand disease duration was calculated by Spearman correlation coefficients .Results The UPDRSⅢ、PSPRS of PSP group were significantly higher than the controls (P<0.05).However,the serum uric acid of PSP group were significantly lower than the controls(P<0.05).When the male and female groups were investigated separately ,the decrease of serum uric acid was more significant in the male groups compared to the female (P<0.01),also lower than the male controls (P<0.01). Serum uric acid in subtypes of the PSP groups were significantly lower than the controls (P<0.05).Serum uric acid was a inverse association between H-Y and UPDRS Ⅲ,however,serum uric acid was in a significantly negative correlation with disease duration(P<0.01).Conclusion The reduced serum uric acid may be associated with PSP ,especially in the male,the lower serum uric acid ,the more severity in PSP;serum uric acid as a natural antioxidant ,it could be a natural pro-tective factor in PSP .%目的 探讨血清尿酸与进行性核上性麻痹(PSP)的相关性.方法 收集71例PSP患者,选取70例健康人群为对照组.采用两独立样本t检验比较PSP组与健康对照组血清尿酸的差异,比较不同性别、PSP各亚型之间以及各亚型与对照组之间血清尿酸差异,采用Spearman分析PSP血清尿酸与Hoehn-Yahr分期、统一帕金森病(PD)评定量表第Ⅲ部分(UPDRSⅢ)评分及病程的相关性.结果 PSP组UPDRSⅢ评分、PSPRS评分明显高于健康对照组(P<0.05).而PSP组尿酸则明显低于健康对照组(P<0.05).按不同性别比较时,男性PSP组尿酸明显低于女性(P<0.01),亦低于男性健康对照组(P<0.01).PSP各亚型尿酸均明显低于健康对照组(P<0.05),差异均有统计学意义.Spearman相关分析,HY分期、UPDRSⅢ评分与尿酸呈明显负相关,而病程与尿酸呈显著负相关(P<0.01).结论 血清尿酸减低可能与PSP患病相关,尤其是男性患者,血清尿酸越低,PSP患病越严重;尿酸作为抗氧化剂,对PSP患者可能具有一定的保护作用.
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