短暂性脑缺血发作对卒中后脑保护的临床观察

摘要

目的 比较短暂性脑缺血发作(TIA)后卒中与无TIA发作脑卒中患者临床预后,探讨体内缺血预适应对脑组织保护机制;方法 选择首次急性脑卒中住院患者340例,按有无TIA发作分为TIA组和无TIA组,观察患者神经功能改善情况及再梗死率,并分析日常生活活动能力恢复程度;结果 与无TIA发作组比较,既往有与此次脑梗死相关TIA组患者临床症状明显改善;结论 TIA作为体内缺血预适应可诱导一系列内源性保护机制减少脑组织损伤.%Objective To compare the protective effect of ischemic preconditioning on brain tissue in patients with transient ischemic attack(TIA)and stroke without TIA;Methods 340 patients with first acute stroke were divided into TIA group and non-TIA group according to the presence or absence of TIA.The improvement of neurological function and reinfarction rate were observed and the degree of recovery of daily living activity was analyzed;Results Compared with the non-TIA attack group,there was a significant improvement in the clinical symptoms of TIA patients associated with this cerebral infarction;Conclusion TIA as an in vivo ischemic preconditioning can induce a series of endogenous protective mechanisms to reduce brain tissue damage.