豆类丝核菌次级代谢产物对小鼠围产期毒性的研究

摘要

[Objective] The research aimed to provide experimental basis for the safe application of secondary metabolites of Rhizotonia legumini cola on mice in the clinic. [Method] The gravid maternal mice were randomly divided into normal control group,group of adding 56.62 mg/kg secondary metabolites of R. Leguminicola, group of adding 14. 15 mg/kg secondary metabolites of R. Leguminicola and group of adding 3. 54 mg/kg secondary metabolites of R. Leguminicola. The toxicity of secondary metabolites of R. Leguminicola on mice in the perinatal period was studied. [Result]The body weight of maternal mice on the 21st day after pregnancy decreased significantly (P 0.05 ) , but the growth index, viscera index,survival time of swimming,development index of reflex and development index of physiology had significant or extremely significant differ ence with control group. [Conclusion]Under these experimental conditions,secondary metabolites of R. Leguminicola had toxicity on mice in the perinatal period.%[目的]为豆类丝核菌次级代谢产物在临床上的安全用药提供试验依据.[方法]将受孕0d的母鼠随机分为正常对照组,豆类丝核菌次级代谢产物56.62、14.15、3.54 mg/kg4个组,研究豆类丝核菌次级代谢产物对小鼠的围产期毒性.[结果]中剂量组母鼠21 d体重显著下降(P＜0.05).各试验组F1代小鼠出生胎数、0d成活率与对照组无显著差异(P＞0.05),而生长指数、内脏指数、游泳生存时间、生理发育指标、反射发育指标与对照组有显著或极显著差异.[结论]在该试验条件下豆类丝核菌次级代谢产物对小鼠有围产期毒性,在临床上作为抗肿瘤药物使用时孕妇应禁用.