四川省不同地区猪源大肠杆菌耐药性调查

摘要

[目的]了解四川省不同地区猪源大肠杆菌的耐药性.[方法] 采用CLSI推荐的微量肉汤稀释法,对分离自四川各地不同养猪场的232株大肠杆菌对32种抗菌药物的耐药性进行调查.[结果] 232株大肠杆菌除对头孢噻呋、头孢唑啉、头孢曲松和阿米卡星较敏感(耐药率≤15.52%)外,对其余28种药物均表现出不同程度的耐药性(耐药率范围42%～97%);98.7%的菌株表现出多重耐药性;对部分药物,分离自规模化养殖场菌株的耐药性比分离自散养户的菌株严重.[结论]分离菌株对大部分抗菌药物均表现出耐药性.%[ Objective ] To get messages of antibiotic resistance in swine E. coli isolates from different areas in Sichuan province. [ Method ] Antibiotic resistance of 232 E. coliisolates from different pig farms in Sichuan province to 32 antimicrobial agents was surveyed. Broth microdilution method according to the recommendation of the CLSI was used. [ Result] Lower antibiotic resistance rate ( ≤15.52％ ) against ceftiofur, cefazolin, amikacin, and higher antibiotic resistance rate(42％ -97％ ) against the other 28 agents were observed in 232 E. coli isolates, respectively. 98.7％ of all isolates possessed multi-drug resistance. To some antibiotics, the antibiotic resistance of E. coli isolates from large scale farms was more serious than isolates from individual farms. [ Conclusion] Antibiotic resistance among the E. coli isolates to most of the antimicrobial agents is existed.