速溶芦笋粉改善睡眠作用研究

摘要

[目的]评价以芦笋为原料开发的功能食品速溶芦笋粉改善睡眠的功效.[方法]通过60名志愿者试食试验,每日食用1次,1次2袋(24 g),连续食用60 d,进行睡眠状况评估,同时测定安全性指标及失眠相关内分泌指标,观察速溶芦笋粉对人体睡眠障碍的改善作用.[结果]速溶芦笋粉可明显增加有失眠困扰测评者的有效睡眠时间,由5.1 h延长至6.1 h;缩短入睡时间,由50.4 min缩短到25.3 min;醒后再入睡时间明显减少,平均时间由46.5 min减少至19.5 min,食用前后差异显著(P<0.05),测评者对睡眠质量改善满意度较高.食用后无肝肾功能影响,具有较好的安全性.速溶芦笋粉可以降低皮质醇、去甲肾上腺素水平,提高5-羟色胺、多巴胺水平.[结论]速溶芦笋粉有改善睡眠质量作用,安全有效,其改善睡眠作用可能与调节HPA轴或5-羟色胺分泌相关.%[Objective] To evaluate the efficacy of instant asparagus powder to improve sleep function as a functional food which was made of asparagus.[Method] The effect of instant asparagus powder on sleep disturbance was observed by 60 volunteers.Two bags of instant asparagus powder(24 g) were took per day for 60 d.Then sleep status was assessed and the safety indexes and insomnia-related endocrine indexes were determined.[Result] Instant asparagus powder could significantly increase the sleep time of sleep disorders from 5.1 h to 6.1 h,shorten the time to fall asleep from 50.4 min to 25.3 min,and reduce the time to fall asleep after the awake from 46.5 min to 19.5 min.The results had significant difference(P<0.05).The satisfaction of sleep quality was high.Instant asparagus powder had good safety without liver and kidney function influence.Instant asparagus powder could reduce the levels of cortisol and norepinephrine and increase the levels of serotonin and dopamine.[Conclusion] The results showed that instant asparagus powder could improve the quality of sleep,which was safe and effective.The improvement of sleep may be related to the regulation of HPA axis or the regulation of serotonin secretion.