早期地塞米松－脑脊液置换治疗蛛网膜下腔出血临床观察

摘要

Objective To observe the early dexamethasone, cerebrospinal fluid replacement for subarachnoid hemor-rhage ( SAH) in the clinical curative effect, for clinical subarachnoid hemorrhage is safe and effective treatment method.Methods We treated 68 cases of SAH patients were randomly divided into two groups ( observation group and control group, 34 cases in each group).Two groups of patients were given conventional treatment, the observation group based on this, the upward dexamethasone cerebrospinal fluid replacement therapy.For 2 weeks after treatment to observe cura-tive effect of the two groups, the incidence of cerebral vasospasm and bleeding again.Results The total effective rate treatment the two groups:observation group and 61.8%in control group 88.2%, two groups are statistically significant ( P <0.05 ); The incidence of cerebral vasospasm:observation group and 20.6% in control group 8.8%, two groups are statistically significant (P<0.05);11.8%incidence of bleeding again:the observation group and 8.8%in control group, the differences between the two groups has no statistical significance ( P>0.05 ).Conclusions Early dexamethasone cerebrospinal fluid replacement as a safe and effective method of treatment of SAH, can obviously allevi-ate the illness and reduce the complications and no obvious side effects of drugs.%目的：观察探讨早期地塞米松－脑脊液置换治疗蛛网膜下腔出血（ SAH）的临床疗效，为临床蛛网膜下腔出血寻找安全有效的治疗方法。方法将救治的68例SAH患者随机分为两组（观察组和对照组、每组34例）。两组患者均给予常规治疗，观察组在此基础上行地塞米松－脑脊液置换治疗。连续治疗2周后观察两组疗效、脑血管痉挛及再出血发生率。结果两组治疗总有效率：观察组88.2％、对照组61.8％，两组比较有统计学差异（ P＜0.05）；脑血管痉挛发生率：观察组8.8％、对照组20.6％，两组比较有统计学差异（ P＜0.05）；再出血发生率：观察组11.8％、对照组8.8％，两组差异无统计学意义（ P＞0.05）。结论早期地塞米松－脑脊液置换作为安全、有效的治疗SAH的方法，能明显缓解病情、减少并发症且无明显的药物毒副作用。