S100P 与 Ki -67在肾盂尿路上皮癌中的表达及意义

摘要

目的：观察 S100P 与 Ki -67蛋白在肾盂尿路上皮癌组织中的表达，分析其与肾盂尿路上皮癌临床病理特征的关系及探讨两者与肾盂尿路上皮癌发生、发展的相关性。方法：采用免疫组织化学 SP 法检测52例肾盂尿路上皮癌与46例正常肾盂黏膜组织中 S100P、Ki -67的表达情况。结果：S100P 在肾盂尿路上皮癌组织中的阳性表达率（86.5％45/52）明显高于正常对照组（30.4％14/46）（P ﹤0.05），同样 Ki -67在肾盂尿路上皮癌组织中的阳性表达率（80.8％42/52）明显高于正常对照组（26.1％12/46）（P ﹤0.05）；S100P、Ki -67在肾盂癌组织中的阳性表达与患者的性别、年龄无关（P ﹥0.05），却与病理分级、临床分期有关（P ﹤0.05）；在肾盂癌组织中，S100P 与 Ki -67表达呈正相关，具有统计学意义（P ﹤0.05）。结论：S100P 与 Ki -67过表达提示其在肾盂尿路上皮癌的发生、发展中具有重要作用，因此联合检测两者可能有助于判断肾盂尿路上皮癌生物学行为及预后评估。%Objective To Investigate the expressions of S100P protein and Ki - 67 in urothelial carcinoma of the renal pelvis,and ana-lyze their expression correlation and clinical significance in urothelial carcinoma of the renal pelvis. Method The expressions of S100P and Ki - 67 were analyze by immunohistochemical in 52 cases of urothelial carcinoma of the renal pelvis and 46 cases of normal pelvis muco-sa. Results The positive rate of S100P protein in urothelial carcinoma of the renal pelvis(86. 5% 45 / 52)was significantly higher than that in normal pelvis mucosa(30. 4% 14 / 46)(P ﹤ 0. 05),Similarly,The positive rate of Ki - 67 protein in urothelial carcinoma of the renal pel-vis(80. 8% 42 / 52)was significantly higher than that in normal pelvis mucosa(26. 1% 12 / 46)(P ﹤ 0. 05);The expression of S100P、Ki -67 was not associate with patient' gender and age(P ﹥ 0. 05),but was associate with pathological degree andclinical stages(P ﹤ 0. 05);meanwhile there was a positive correlation between expression of S100P and Ki - 67. Conclusion The over - expression of S100P、Ki - 67 is important for the development and progression of renal previc carcinoma,and It is helpful to detect the two markers together for predicting urothelial carcinoma of the renal pelvis biological behavior and prognosis.