Objective To explore the effectiveness of fasting time on serum creatinine and serum cystatin levels in the full—term newbo-creatinine and serum cystatin levels of the child were detected. Fasted 3 hours,24 hours,48 hours,one hour before eating and after eating 48 hours of serum creatinine and cystatin levels of cases group were detected,in the meantime,other forms of treatment remained the same,not to choose effect on jidney's drugs. Results Compared serum creatinine levels:cases group and control group( t=7. 72,P<0. 000 1),cases group fasted 3 hours and fasted 24 hours,48 hours(F=4. 09,P=0. 024 9),one hour before eating and after eating 48 hours(t=8. 50,P<0. 000 1),the differences were statistically significant. Compared serum cystatin levels:cases group and control group,the difference was statis-tically significant(t=3. 37,P=0. 0012),one hour before eating and 48 hours after eating in cases group(t=1. 98,P=0. 054 5),fasted 3 hours and fasted 24 hours,48 hours(F=2. 51,P=0. 094 9),the difference was not statistically significant(P>0. 05). Conclusion The full—term newborns with hypoxic—ischemic encephalopathy fasting for a long time,might elevate the levels of serum creatinine and serum cysta-tin. In the case of the clinical condition permitted,shorten fasting time.%目的：探究足月新生儿在缺氧缺血脑病状态下，禁食时间长短对血肌酐和血胱抑素水平的影响情况。方法：将所观察的80例足月新生儿依据病史、症状和体征分为病例组与对照组。检测收治6 h内血肌酐和血胱抑素水平。检测病例组禁食3 h、24 h、48 h和进食前1 h及进食后48 h的血肌酐和血胱抑素水平，在此期间，其他治疗方式保持不变，未选用对肾脏有影响的药品。结果：血肌酐水平比较：病例组与对照组（t=7.72，P<0.0001），病例组禁食3 h与禁食24 h、48 h（F=4.09，P=0.0249），病例组进食前1 h与进食后48 h（t=8.50，P<0.0001），差异均有统计学意义。血胱抑素水平比较：病例组与对照组，差异有统计学意义（t=3.37，P=0.0012），病例组进食前1 h与进食后48 h（t=1.98，P=0.0545）与病例组禁食3 h与禁食24 h、48 h（F=2.51，P=0.0949），差异均无统计学意义（P<0.05）。结论：缺氧缺血脑病足月新生儿禁食时间过长可能引起血肌酐、血胱抑素水平升高，建议在临床病情容许的情况下，缩短禁食时间。
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