Objective Compare the magnesium sulfate and the curative effect of theophylline drugs in the treatment of chil-dren with asthmatic diseases.Method 255 cases of children with asthmatic diseases of children were seleded,according to differ-ent choice antiasthmatic content they were divided into sulfuric acid group,the doxofylline group,2 hydroxypropyl theophylline group,aminophylline group.Four groups of children were given anti -infection,antiviral,reduce phlegm and atomization inhala-tion based on comprehensive treatment,each group separately using magnesium sulfate in the intravenous drip antiasthmatic,doxo-fylline,2 hydroxypropyl theophylline,aminophylline,such as treatment was invalid,combined with hormone and asthma,retrospec-tive comparison the clinical manifestations of the four groups of children,to analyze its signs and symptoms of ease.Results Magnesium sulfate groups of children with cough,wheezing,pulmonary symptoms disappear time and hospital stay compared with theophylline three groups were significantly shortened,and the total effective rate 96.97%,significantly higher than the other theophylline three groups.The differences were statistically significant (P <0.05).Conclusion Intravenous drip small doses of magnesium sulfate treatment of pediatric asthmatic diseases with fast had marked effect,good curative effect,safe and non -toxic side effects,worthy of clinical promotion.%目的：探讨对比硫酸镁与茶碱类药物在治疗小儿喘息性疾病中的疗效差异。方法：选取255例患小儿喘息性疾病的患儿，根据选择平喘药物不同分为硫酸镁组、多索茶碱组、二羟丙茶碱组、氨茶碱组。四组患儿均给予相应抗感染、抗病毒、止咳化痰、雾化吸入等综合治疗，在此基础上各组在平喘药上分别采用硫酸镁、多索茶碱、二羟丙茶碱、氨茶碱，治疗无效时，加用激素平喘，回顾性比较四组患儿的临床表现，分析其症状、体征的缓解情况。结果：硫酸镁组患儿的咳嗽、喘息、肺部体征消失时间及住院时间与茶碱三组比较均明显缩短，总有效率96.97％，明显高于其他三组，差异均有统计学意义（P ＜0.05）。结论：静脉滴注小剂量硫酸镁治疗小儿喘息性疾病具有显效快，疗效确切，安全无毒不良反应等优点，值得临床推广。
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