抗心磷脂抗体、狼疮抗凝物、抗β2－糖蛋白Ⅰ抗体对反复种植失败影响的研究

摘要

目的：探讨反复种植失败（RIF）与抗磷脂抗体（APA）包括抗心磷脂抗体（ACA）、狼疮抗凝物（LA）、抗β2－糖蛋白Ⅰ抗体（抗β2－GPⅠ抗体）的关系。方法：对96例 RIF 患者（研究组）和225例同期行体外受精－胚胎移植（IVF －ET）的患者（对照组），分别采用酶联免疫吸附法和部分凝血酶原时间法，联合检测静脉血清中的 ACA、LA、抗β2－GPⅠ抗体。结果：研究组中 ACA、LA、抗β2－GPⅠ抗体的阳性百分比，单个抗体检测和多个抗体联合检测均高于对照组，差异有统计学意义（P ＜0.05）。结论：ACA、LA、抗β2－GPⅠ抗体与 RIF 有关，对 RIF 患者，应常规筛查 APA，以期对其早期干预，进而提高 IVF －ET 的临床妊娠率，降低流产率。%Objective To investigate the relationship between women with repeated implantation failure and anti -phospho-lipid antibodies,Including ACA、LA and anti -β2 -GPⅠantibody.Method Levels of serum APA including ACA、LA and anti -β2 -GPⅠantibody were determined by enzyme linked immune -absorbent assay and activated partial thromboplastin time meth-od respectively in 96 patients with history of repeated implantation failure(study group)and 225 normal patients with IVF -ET (control group).Results The positive rates of ACA、LA and anti -β2 -GPⅠantibody in the study group were significantly high-er than those in controls group(P <0.05).Conclusion Levels of ACA、LA and anti -β2 -GPⅠ antibody are associated with re-peated implantation failure,Therefore routine screening of serum APA in patients with repeated implantation failure for the sake of early diagnosis and treatment,to improve the rate of pregnancy and reduce the abortion of IVF -ET.