卵泡期联合黄体期促排卵在卵巢低反应患者实施辅助生殖技术中的应用

摘要

目的：比较拮抗剂方案和微刺激联合黄体期促排卵方案在卵巢低反应患者实施辅助生殖技术中的效果，探讨在卵巢低反应患者中黄体期促排卵应用价值。方法：回顾性分析行 IVF －ET 的卵巢低反应患者共104个周期，A 组拮抗剂方案（56个周期），B 组微刺激联合黄体期促排卵方案（48个周期），比较两组的基本情况及助孕结局。结果：A 组的平均促性腺激素（Gn）天数、Gn 用量获卵数、MⅡ卵数、可移植胚胎数均显著低于 B 组，差异有统计学意义（P ＜0.05）；在联合促排卵组中，扳机日黄体期的 E2、P 水平明显升高，LH 水平明显较低，差异有统计学意义（P ＜0.05）。黄体期平均获卵数、MⅡ卵数均显著高于卵泡期（P ＜0.05），而受精率和平均优质胚胎率均无统计学差异（P ＞0.05）。两组促排卵周期妊娠率无统计学差异（P ＞0.05）。结论：卵泡期联合黄体期方案是卵巢低反应患者较理想的促排卵方案。%Objective To compare the effects of antagonist protocol and micro -stimulation combined with luteal -phase ovula-tion induction undergone assisted reproductive technology of patients with poor ovarian response(POR),to explore the effection of luteal -phase ovulation induction in patients with POR.Method A total of 104 clinical cases with POR undergoing IVF -ET were analyzed retrospectively,then they were divided into group A(antagonist programs,56 cycles)and group B(micro -stimulation com-bined with luteal -phase ovulation induction,48 cycles).Compared of the basic situations and pregnancy outcomes in the two groups.Results The mean time of gonadotropin (Gn),the dosage of gonadotrophin,the number of retrieved oocytes,the number of MⅡegg cleavage,and available embryos in group A were statistically significantly lower than those in group B,the difference was statistically significant (P <0.05);In sequential ovarian stimulation cycle,compared of the endocrine in trigger day.The E2 and P level in luteal phase were statistically significantly higher than those in follicular phase,then the LH level was lower,the difference was statistically significant (P <0.05).The number of oocytes and MⅡegg cleavages retrieved cycle in the luteal stimulation phase was significantly more than in follicular phase,the difference was statistically significant (P <0.05).But the fertilization rate and the good -quality embryos rate were not significantly different(P >0.05).The cycle pregnancy rate of ovulation induction was no statistically significant difference between group A and group B(P >0.05).Conclusion Sequential ovarian stimulation is an ideal program for patients with POR.