目的：本研究探讨输尿管下段结石在钬激光碎石术后辅助应用α1－受体阻滞剂坦索罗辛的临床疗效。方法：选取112例行输尿管镜钬激光碎石＋双 J 管置入术患者。患者被随机分为两组，研究组56例患者接受坦索罗辛（0.4 mg／d，口服）与常规治疗（必要时给予镇痛药物），对照组56例患者接受常规治疗。两组术后2周后取出双 J 支架，比较两组术后结石排出率、下尿路刺激症状及肾绞痛发生率、镇痛剂（双氯芬酸钠）使用率。结果：试验组的结石排出率明显高于对照组，差异有统计学意义（P ＜0.05），试验组肾绞痛发生率、镇痛剂使用率低于对照组，差异有统计学意义（P ＜0.05）。结论：与对照组相比，术后辅助应用α1－受体阻滞剂坦索罗辛能明显提高结石清除率，降低术后肾绞痛发生率，减少镇痛剂的使用率。%Objective In this study we aimed to assess the clinical efficacy of tamsulosin after ureteroscopy and holmium litho-tripsy for lower ureteral stones.Method In the prospective study by a randomized clinical trial,a total of 112 patients were en-rolled.All the patients underwent ureteroscopy and holmium lithotripsy.The patients were randomly divided into 2 groups:the study group including 56 patients,received tamsulosin with our traditional treatment (analgesic when required),and the control group with 56 patients who received traditional treatment.Double J stent was left indwelling for 2 weeks postoperatively in both groups.The number of colic episodes,lower urinary tract symptoms,analgesic dosage were recorded after lithotripsy.Results The results showed that tamsulosin treatment group had higher the stone -free rate,least analgesic needs and colic episodes,all with statistically signifi-cant differences comparable with the control group (P <0.05).Conclusion Administration of tamsulosin after ureteroscopy and holmium lithotripsy for ureteral stone can increase the stone -free rate,reduced the incidence of colic episodes and decreased the usage of analgesics.
展开▼
