目的 探讨健脾化湿调肝方治疗腹泻型肠易激综合征(D-IBS)伴焦虑和/或抑郁状态患者的临床疗效.方法 选取我院中医科就诊的60例D-IBS伴焦虑和/或抑郁状态患者,随机分为治疗组和对照组,每组30例.治疗组给予健脾化湿调肝方,对照组给予枯草杆菌二联活菌肠溶胶囊联合氟哌噻吨美利曲辛,2组均治疗4周,观察并比较临床疗效及安全性.结果 对比2组的消化道症状评分,治疗组的大便溏薄、少腹胀满、少腹疼痛症状评分优于对照组(P＜0.05),均有统计学意义.在临床疗效方面,治疗组总有效率87%,对照组总有效70%,2组相比P＜0.05,有统计学意义.同时,治疗组精神情绪状态改善程度皆优于对照组(P＜0.05).2组均未发现明显不良反应.结论 中药健脾化湿调肝方通过脑肠轴的作用可明显提高D-IBS伴焦虑和或抑郁状态的临床疗效.%Objective To observe the clinical efficacy of D-IBS with anxiety and/or depression by strengthening spleen, resolving dampness and regulating liver. Methods 60 cases of D-IBS with anxiety and depressive status were selected in our hospital, randomly divided into treatment group and control group, 30 cases in each group. the treatment group was given traditional Chinese medicine decoction, the control group was given Medilac-S combined with Flupentixol and Melitracen, the two groups were treated for 4 weeks to observe and compare the clinical efficacy and safety. Results Compared with the two groups, the scores of fecal pelvic thin, lower abdomen fullness and lower abdomen pain in the treatment group were better than those in the control group (P＜ 0.05), both of which were statistically significant. In the clinical efficacy, the total effective rate of 87% in the treatment group, the total effective control group 70%, compared with the two groups P＜ 0.05, statistically significant. At the same time, the mental state of the treatment group was better than that of the control group (P＜0.05). No significant adverse reactions were found in either group. Conclusion Chinese medicine of Strengthening spleen, resolving dampness and Regulating liver can significantly improve clinical efficacy of the D-IBS with anxiety and or depression.
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