目的：研究黄龙止咳口服液的抗炎、抗过敏作用。方法建立角叉菜胶致大鼠足趾肿胀模型，测量并比较致炎后不同时间点大鼠的足趾周长，观察黄龙止咳口服液的抗炎作用。采用2，4－二硝基氯苯（DNCB ）背部皮下致敏、耳廓发敏的方法建立迟发型超敏反应小鼠模型，观察黄龙止咳口服液的抗过敏作用。结果抗炎实验表明，黄龙止咳口服液对角叉菜胶所致大鼠足爪炎性水肿有显著抑制作用，能抑制炎症的发展，加速其消退，并显示一定的量－效关系。抗过敏实验表明，与对照组比较，黄龙口服液各剂量组均可使DNCB所致的小鼠耳肿胀程度明显减轻。结论黄龙止咳口服液具有显著的抗炎和抗过敏作用。%Objective To study the anti-inflammatory ,anti-allergic effect of huanglong cough oral liquid .Methods Estab-lish carrageenan to toes swelling of rats' model ,measure and compare the different time points after inflammatory rats toes circumference ,anti-inflammatory effect of observation of huanglong cough oral liquid .The 2 .4-2 nitrochlorobenzene (DNCB ) back under the skin sensitization ,auricle of sensitive method to establish delayed-type hypersensitivity in mice model ,to ob-serve the allergy of huanglong cough oral liquid .Results Anti-inflammatory experiments show that the huanglong cough oral liquid diagonal inflammatory edema caused by carrageenan in rats foot claw has significant inhibitory effect ,can restrain the development of inflammation ,accelerate its faded ,and displays a certain amount-effect relationship .Allergy experiments show that ,compared with control group ,the yellow dragon oral liquid in each dose group can make the mouse ear swelling caused by DNCB significantly reduce .Conclusion Huanglong cough oral liquid has significant anti-inflammatory and anti-allergic effects .
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