Objective To explore the effect of Guizhi Fuling pill combined with mifepristone in the treatment of hysteromyoma and the influence on hemorheology. Methods A total of 74 cases of hysteromyoma in our hospital from May. 2014 to Mar. 2016 were elected and divided randomly into control group (n=37) and observation group (n=37), control group were treated with mifepristone alone, while observation group were treated combined withGuizhi Fuling pill based on the control group, 2 groups were treated continuously for 3 months. Statisticsed the efficacy of 2 groups, compared the clinical symptoms improved conditions and the changes of fibroid volume before and after treatment;Detected and compared the sex hormone levels and hemorheology indexes in 2 groups before and after treatment. Results The total effective rate of observation group was 91.89%, which was higher than 72.97% of control group (P<0.01); Compared with before treatment, the proportion of hypermenorrhea, menostaxis, dysmenorrhea, Waist and abdominal distension painful in 2 groups and the proportion of irregular vaginal bleeding decreased significantly after treatment , and which in observation group were lower than that in control group significantly (P<0.05 or P<0.01). The fibroid volume decreased significantly in 2 groups after treatment, and observation group was (2.02±0.83) cm3, which was less than that (3.21±0.81) cm3 of control group (P<0.01). Compared with before treatment, the levels of serum E2, LH, FSH and P and the whole blood high shear viscosity, whole blood low shear viscosity, blood viscosity and ARBC decreased significantly in 2 groups after treatment (P<0.05 or P<0.01), excepted LH, the above indicators of observation group were lower than that of control group (P<0.01). Conclusion Guizhi Fuling pill combined with mifepristone can reduce serum sex hormone levels and blood viscosity of hysteromyoma patients, and decrease the fibroid volume, improve the clinical symptoms, the efficacy is superior to mifepristone significantly.%目的 探讨桂枝茯苓丸配合米非司酮治疗子宫肌瘤的疗效及对患者血液流变学的影响.方法 选取2014年5月-2016年3月本院收治的子宫肌瘤患者74例,将患者随机分为对照组及观察组各37例,对照组给予单纯的米非司酮治疗,观察组在对照组的基础上联合桂枝茯苓丸治疗,2组均连续治疗3个月.统计2组临床疗效;比较2组治疗前后临床症状改善情况及肌瘤体积的变化;检测并比较2组治疗前后血清性激素水平及血液流变学指标水平.结果 治疗后观察组总有效率为91.89%,显著高于对照组的72.97%(P<0.01);与治疗前比较,治疗后2组月经过多、经期延长、痛经、腰腹胀痛患者比例及观察组阴道不规则出血患者比例均明显降低,且观察组显著低于对照组(P<0.05或P<0.01);治疗后2组肌瘤体积均明显减小,且观察组为(2.02±0.83)cm3,显著小于对照组的(3.21±0.81)cm3(P<0.01);与治疗前比较,治疗后2组患者血清E2、LH、FSH、P水平及全血高切黏度、全血低切黏度、血黏度及ARBC均明显降低(P<0.05或P<0.01),除LH外,观察组上述指标明显低于对照组(P<0.01).结论 桂枝茯苓丸联合米非司酮可显著降低子宫肌瘤患者血清性激素水平,降低患者血液黏度,肌瘤体积明显减小且临床症状得到显著改善,疗效明显优于米非司酮单独治疗.
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