消渴明目汤治疗单纯型糖尿病视网膜病变

摘要

Objective To observe the clinical effect of Xiaoke Mingmu Decoction in the treatment of simple diabetic retinopathy (DR).Methods 74 DR cases which selected from January 2014 to December 2015 in our hospital were randomly divided into Xiaoke Mingmu Decoction group (n=38,74 eyes) and calcium dobesilate group (n=36,71 eyes) Xiaoke Mingmu Decoction and calcium dobesilate were given respectively.The two groups were all treated for 12 weeks.Observed the change of scores of TCM syndromes,visual acuity and fundus changes,and fasting blood glucose,postprandial 2h blood glucose,total cholesterol,triglyceride,glycosylated hemoglobin and so on before and after treatment.Results The total effective rate were 78.95％ and 72.22％ in Xiaoke Mingmu Decoction group and calcium dobesilate group respectively,the difference of the efficacy in the two groups had no significant (P＞0.05),the TCM syndromes after treatment in Xiaoke Mingmu Decoction group were significantly decreased than calcium dobesilate group at the same period (P＜0.05).Conclusion Xiaoke Mingmu Decoction can effectively relieve fundus microcirculation disturbance,blood vessels and blood flow changes,bleeding,exudation of DR patients%目的 观察消渴明目汤治疗单纯型糖尿病视网膜病变(Diabetic retinopathy,DR)的临床疗效.方法 选取2014年1月-2015年12月我院收治的DR患者74例,随机分为消渴明目汤组38例(74眼)及羟苯磺酸钙组36例(71眼),分别予消渴明目汤和羟苯磺酸钙治疗;2组均治疗12周.观察治疗前后中医证候积分、视力和眼底变化,以及空腹血糖、餐后2h血糖、总胆固醇、三酰甘油、糖化血红蛋白等指标变化.结果 消渴明目汤组及羟苯磺酸钙组治疗总有效率分别为78.95％和72.22％,2组疗效差异无统计学意义(P＞0.05),消渴明目汤组治疗后中医证候积分明显低于同期羟苯磺酸钙组(P＜0.05).结论 消渴明目汤能有效缓解DR患者眼底微循环障碍、血管及血流改变、出血、渗出等.