环孢素A与阿维A治疗泛发性脓疱型银屑病的疗效观察

摘要

Objective To discuss the clinical efficacy of CysA and acitretin in treatment of refractory generalized pustular pso-riasis (GPP). Methods 60 cases with generalized pustular psoriasis were randomly divided into A group and B group,each of 30 cases. A group was treated with CysA,and B group was with Acitretin. The clinical efficacy,the average times for symptoms and signs to disappear,relapse rate and adverse effects was compared between 2 groups respitively. Results The total effective rate and recurrence rate of A group were80.0%,10.0% respectively,which of B group were 86.7%,13.3% respectively,there were no significant difference between 2 groups (P>0.05). The recovery time of temperature and the recession time of erythema and pustule of A group were shorter than that of B group;hypertension cases of A group were more than B group;and dysfunction of liver and dyslipidemia. of A group were less than that of B group,the differences were statistically significant(P<0.01 and P<0.05). Conclu-sion No significant differences in efficacy were found between CysA and acitretin for the treatment of GPP. CysA may represent an alternative therapeutic option, when Acitretin are unsuccessful.%目的：探讨环孢素A与阿维A治疗泛发性脓疱型银屑病(GPP)的临床疗效。方法将60例GPP随机均分为A组和B组，A组采用环孢素A治疗、B组采用阿维A治疗。比较两组的临床疗效、症状和体征消失时间、复发率及不良反应。结果 A 组总有效率和复发率分别为80.0%、10.0%，B组为86.7%、13.3%，两组比较差异均无统计学意义(P＞0.05)。 A组体温恢复正常时间及红斑、脓疱消退时间短于B组。血压升高发生率高于B组，肝功能损害和血脂异常发生率低于B组，差异均有统计学意义(P＜0.01和P＜0.05)。结论环孢素A与阿维A治疗GPP效果相似。当阿维A治疗GPP无效，可选用环孢素A作为替代药物治疗。