川芎嗪、尼莫通对大鼠脑出血后局部脑血流量、脑水份含量及神经行为学干预作用的研究

摘要

目的采用立体定向术和新鲜未肝素化血液注入尾状核而建立大鼠脑出血模型，观察用药物干预后的脑出血组较单纯脑出血组在局部脑血流量(rCBF)、脑水份含量及神经行为学方面的变化。方法用氢清除法分别测定血肿周围和远隔部位不同时限的rCBF；用干—湿重法测定两组大鼠脑出血后不同时间和不同部位的脑水份含量；观察两组大鼠在脑出血后不同时限的神经行为学评分的改变。结果川芎嗪、尼莫通干预后的脑出血组血肿周围及远隔部位的rCBF明显增加，脑水份含量降低，神经行为学明显改善，与单纯出血组比较有显著性差异（P≤0.05或0.01）。结论川芎嗪、尼莫通对实验性脑出血有疗效。%Objective　The nonheparinized arterial blood was injected into the caudate nucleus of the rat to establish a model of ICH（intracerebral hemorrhage）in this study．Comparing the groups of ICH With the groups of ICH that were intervened by LZ, NM to observe the changes of rCBF，brain water content，neurological symptoms．Methods　To measure different time rCBF of the brain surrounding the hematoma and distant structures by hydrogen clearance method．Brain water content in R1，R2，R3，R4at 4，12and 24 hours after ICH were determined by the wet and dry weighing method，neurological symptoms evaluation was undergone at 4，12，24，48 and 72 hours after experimental ICH．Results　The results were as follows：In the areas of around the hematoma and distant from hematoma of the ICH groups，which were intervened by LZ and NM，rCBF were increased evidently，brain water content were reduced，neurological symptoms were improred obviously，there were obviously diffrence（P＜0.05 or 0.01）by comparing with the groups of ICH．Conclusion　LZ，NM could improve rCBF，brain water content and neurological symptoms after ICH in rats．