Objectives To investigate the clinical values of three serum marker l evel alteration in diagnosis and differe ntial diagnosis of primary hepatocellula r carcinoma （PHC）．Methods The he patoma s pecific band（HSB） activities of serum GG T，the levels of serum ferritin （SFn） and lipid associated sialic acid （LSA） were quantitated in different patients with liver diseases．Results The conce ntration s of HSB in patients with PHC （before tr anscatheter arterial embolization）increa sed significantly in comparison with chr onic liver diseases and other tumors （P ＜0.001）．The concentrations of SFn and L SA in PHC were significantly higher than those in chronic liver diseases，but no d ifferentiation was found between PHC and other tumor groups．The incidence of HSB ，S Fn and LSA in PHC group was 100％，53.3％ a nd 67.8％，respectively．Conclusion The qua ntitative analysis of HSB activities of GGT is superior to that of SFn and LSA．T he combined detection of several markers was helpful to diagnosis and differenti al diagnosis of PHC．%目的探讨肝癌特异性γ-谷氨酰转肽酶、铁蛋白和脂质结合唾液酸浓度改变在肝癌诊断与鉴别中的临床价值。方法分别定量检测了肝癌、慢性肝病和肝外肿瘤患者血清中肝癌特异性GGT同工酶区带（HSB）、铁蛋白（SFn）和脂质结合唾液酸（LSA ）浓度。结果肝癌组血清HSB浓度TAE前明显异常，同时也高于慢性肝炎、肝硬化和肝外肿瘤病人（P＜0.001）；SFn和LSA水平肝癌组明显高于慢性肝病患者，但与其他肿瘤无鉴别价值；肝癌组HSB、SFn和LSA的阳性率分别为100％、53.3％和67.8％。结论 HSB定量和定性检测均优于SFn和LSA的浓度分析，多项指标联合分析有助于肝癌的诊断与鉴别
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