戊乙奎醚在肺叶切除术患者的应用

摘要

Objective To investigate the application outcomes of penehyclidine in the patients undergoing pulmonary lobectomy. Methods Thirty ASA I - Ⅱ male patients undergoing pulmonary lobectomy were divided into groups of A( 65-75 years old) and B(45-55 years old) with 15 cases each. The patients in group A received penehyclidine 0.01 mg/kg and 0.02 mg/kg at 20 minutes before surgery and beginning of one-lung ventilation, respectively, and those in group B were given atropine 0.01 mg/kg instead of penehyclidine as in group A. HR, MAP, tidal volume (VT), peak airway pressure(Ppeak) and PETCO2 at Tl(two-lung ventilation),T2(one-lung ventilation),T3(5 min after one-lung ventilation) and T4(20 min after one-lung ventilation) were compared between two groups. Results Compared with Tl and group B, VT was increased at T3 and T4 in group A(P<0. 05). Compared with Tl and group A,Ppeak was increased at T3 and T4 in group B(P<0. 01). There was no significant difference in hemodynamic index and PET COZ between two groups. Conclusion Penehyclidine can dilate the bronchi and increase lung compliance in aged patients undergoing pulmonary lobectomy.%目的 探讨戊乙奎醚在肺叶切除术患者的应用价值.方法 30例ASA Ⅰ-Ⅱ级男性肺叶切除患者分为A组(年龄65-75岁)和B组(年龄45-55岁),每组15例.A组术前20min、单肺通气时分别给予戊乙奎醚0.01、0.02m/kg,B组术前20 min、单肺通气时均给予阿托品0.01 mg/kg.检测两组双肺通气(T1)时、单肺通气0.5.20min(T2、T3、T4)时的MAP、HR、潮气量(VT)、气道峰压(Ppeak)、PETCO2.结果 与T1时及B组相比,A组T3、T4时VT明显增加(P＜0.05);与T1时及A组相比,B组T3、T4时Ppeak明显增加(P＜0.01);两组MAP、HR、PETCO差异均无统计学意义.结论 戊乙奎醚可以明显扩张肺叶切除术老年患者支气管,增加肺顺应性.