巨噬细胞移动抑制因子对2型糖尿病患者血管病变的影响

摘要

Objective To investigate the changes of the serum contents of macrophage migration inhibitory factor(MIF) and its effect on the development of angiopathy in the patients with type-2 diabetes mellitus (T2DM). Methods Serum MIF and high-sensitivity C-reactive protein (hs-CRP) were detected with ELISA in 19 T2DM cases with angiopathy (group A) and 19 T2DM without angiopathy (group B) and 16 healthy persons (group C). The contents of blood glucose (BG) and glycosylated hemoglobin A-lc(HbAlc) were tested as well. Results Serum levels of MIF and hs-CRP were higher in groups of A and B than those in group C. Serum hs-CRP was positively correlated to BG in group A. Serum MIF was positively correlated to hs-CRP and BG, and hs-CRP was positively correlated with BG and HbA1c in group B. Conclusion High expressions of MIF and hs-CRP are the important factors to promote the development of angiopathy in the patients with T2DM.%目的 探讨2型糖尿病(T2DM)患者血清巨噬细胞移动抑制因子(MIF)水平变化及其对糖尿病血管病变的影响.方法 用ELISA法检测T2DM合并血管病变患者(A组,19例)、T2DM无血管病变患者(B组,19例)和健康体检者(C组,16例)血清MIF和超敏C反应蛋白(hs-CRP).同时检测血糖(BG)和糖化血红蛋白(HbAlc).结果 A组和B组MIF、hs-CRP水平均高于C组(P＜0.01).A组hs-CRP与血糖呈正相关.B组MIF与hs-CRP、BG水平呈正相关,hs-CRP与BG、HbAlc水平呈正相关.结论 糖尿病血管病变患者MIF与hs-CRP高表达是促进血管病变发生的重要因素.